Having said that, I wouldn’t want to live that long either.

A quibble though. That we die when we currently do is not what nature intended, as nature doesn’t intend at all. In logic they call this the fallacy from nature, and it’s a real dangerous one when it starts getting in the way of doing the right thing. Nature isn’t conscious. I am. And you are. And we are going to be tortured to death over a period that may span many years unless we stop that from happening. Aging makes people very, very sick. It doesn’t just kill them. It butchers their bodies and minds by incremental injury. It’s a moral imperative that we treat aging as humanities biggest health problem and do something about it right now.

To whatever extent solving aging may be ‘unnatural’, it’s also ‘good’, which is much, much better. After all, a lot of things that make our lives better are unnatural. Without ‘unnatural’ we’d still be living in caves with a life span of twenty three.

To comment on a few points:

“How would I look and feel after 500 years of gravity pulling on my skin and compressing my bones?”

Were we successful, you would look and feel as you did when you were twenty. That’s the whole point. Extending life by extending youth.

“Part of life is about making a difference, and then making room for the next generation. ”

Things change. In the future the difference we make is one we will get to share. I can’t think of a greater gift to give the next generations than the gift of long lasting youth and good health.